Molecular weight (DA)
64kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ME1. AA range:468-517
Specificity
Malic enzyme 1 Polyclonal Antibody detects endogenous levels of Malic enzyme 1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008],
Function
catalytic activity:(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH.,cofactor:Divalent metal cations. Prefers magnesium or manganese.,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the malic enzymes family.,subunit:Homotetramer.,tissue specificity:Expressed in all tissues tested including liver, placenta and white adipose tissue.,
Protein name
NADP-dependent malic enzyme
Abbreviation
Malic enzyme 1
Other name
ME1; NADP-dependent malic enzyme; NADP-ME; Malic enzyme 1
Fields
>>Pyruvate metabolism;>>Metabolic pathways;>>Carbon metabolism;>>PPAR signaling pathway
Human protein sequence Database
P48163
Mouse protein sequence database
P06801
Rat protein sequence database
P13697
Cellular localization
Cytoplasm .
Tissue expression
Expressed in all tissues tested including liver, placenta and white adipose tissue.
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