Molecular weight (DA)
61kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MAO-A. AA range:298-347
Specificity
MAO-A Polyclonal Antibody detects endogenous levels of MAO-A protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012],
Function
catalytic activity:RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2).,cofactor:FAD.,disease:Defects in MAOA are the cause of Brunner syndrome (BRUNS) [MIM:300615]. Brunner syndrome is a form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior.,function:Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.,mass spectrometry: PubMed:11812236,online information:Monoamine oxidase entry,similarity:Belongs to
Protein name
Amine oxidase [flavin-containing] A
Other name
MAOA; Amine oxidase [flavin-containing] A; Monoamine oxidase type A; MAO-A
Fields
>>Glycine, serine and threonine metabolism;>>Arginine and proline metabolism;>>Histidine metabolism;>>Tyrosine metabolism;>>Phenylalanine metabolism;>>Tryptophan metabolism;>>Drug metabolism - cytochrome P450;>>Metabolic pathways;>>Serotonergic synapse;>>Dopaminergic synapse;>>Parkinson disease;>>Cocaine addiction;>>Amphetamine addiction;>>Alcoholism
Human protein sequence Database
P21397
Mouse protein sequence database
Q64133
Rat protein sequence database
P21396
Cellular localization
Mitochondrion outer membrane ; Single-pass type IV membrane protein ; Cytoplasmic side .
Tissue expression
Heart, liver, duodenum, blood vessels and kidney.
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