Molecular weight (DA)
151kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 700-780
Specificity
NID2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
nidogen 2(NID2) Homo sapiens This gene encodes a member of the nidogen family of basement membrane proteins. This protein is a cell-adhesion protein that binds collagens I and IV and laminin and may be involved in maintaining the structure of the basement membrane.[provided by RefSeq, Jun 2010],
Function
function:Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions.,PTM:Highly N- and O-glycosylated.,similarity:Contains 1 NIDO domain.,similarity:Contains 1 nidogen G2 beta-barrel domain.,similarity:Contains 2 thyroglobulin type-1 domains.,similarity:Contains 5 EGF-like domains.,similarity:Contains 5 LDL-receptor class B repeats.,subunit:Interacts with LAMA2 (By similarity). Interacts with COL13A1.,tissue specificity:Heart, placenta and bone. Less in pancreas, kidney and skeletal muscle.,
Protein name
Nidogen-2 (NID-2) (Osteonidogen)
Human protein sequence Database
Q14112
Mouse protein sequence database
O88322
Rat protein sequence database
B5DFC9
Cellular localization
Secreted, extracellular space, extracellular matrix, basement membrane.
Tissue expression
Heart, placenta and bone. Less in pancreas, kidney and skeletal muscle.
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