Immunogen
The antiserum was produced against synthesized peptide derived from human USP6NL. AA range:451-500
Specificity
RN-tre Polyclonal Antibody detects endogenous levels of RN-tre protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:Acts as a GTPase-activating protein for RAB5A. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 Rab-GAP TBC domain.,subunit:Interacts with EPS8.,tissue specificity:Widely expressed.,
Function
function:Acts as a GTPase-activating protein for RAB5A. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 Rab-GAP TBC domain.,subunit:Interacts with EPS8.,tissue specificity:Widely expressed.,
Protein name
USP6 N-terminal-like protein
Other name
USP6NL; KIAA0019; USP6 N-terminal-like protein; Related to the N-terminus of tre; RN-tre
Human protein sequence Database
Q92738
Mouse protein sequence database
Q80XC3
Rat protein sequence database
Cellular localization
Golgi apparatus. Cytoplasmic vesicle.
Tissue expression
Widely expressed.
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