Molecular weight (DA)
42kD
Immunogen
Synthesized peptide derived from human Actin-pan (Acetyl Lys63/61/62)
Specificity
This antibody detects endogenous levels of Human,Mouse,Rat Actin-pan (Acetyl Lys63/61/62)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008],
Function
disease:Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.,function:Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.,miscellaneous:In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actin
Gene Name
ACTA2 ACTSA ACTVS GIG46
Protein name
Actin-pan (Acetyl Lys63/61/62)
Other name
Actin, aortic smooth muscle (Alpha-actin-2;Cell growth-inhibiting gene 46 protein)
Fields
>>Vascular smooth muscle contraction;>>Apelin signaling pathway;>>Relaxin signaling pathway
Human protein sequence Database
P62736/P60709/P68032/P63261/P63267/P68133
Mouse protein sequence database
P62737
Rat protein sequence database
P62738
Cellular localization
Cytoplasm, cytoskeleton.
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