Molecular weight (DA)
55/65kD
Immunogen
Purified recombinant mouse KLF4 protein fragments expressed in E.coli.
Specificity
Transfected Only.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015],
Function
function:Transcription factor which acts as both an activator and repressor. Binds the CACCC core sequence. Binds to multiple sites in the 5'-flanking region of its own gene and can activate its own transcription. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,subunit:Interaction with the C-terminal domain of MUC1 enhances suppression of TP53/p53 transcription.,
Other name
Endothelial Kruppel like zinc finger protein;Epithelial zinc finger protein EZF;EZF;GKLF;Gut-enriched krueppel-like factor;KLF;KLF4;KLF4_HUMAN;Krueppel-like factor 4;Kruppel like factor 4 (Epithelial zinc finger protein EZF) (Gut enriched Krueppel like factor);Kruppel like factor 4 (gut).
Fields
>>Signaling pathways regulating pluripotency of stem cells;>>Chemical carcinogenesis - receptor activation
Human protein sequence Database
O43474
Mouse protein sequence database
Q60793
Rat protein sequence database
Cellular localization
Nucleus.
Tissue expression
Cervix,Lung,Placenta,Substantia nigra,Tongue,
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