Molecular weight (DA)
300kD
Immunogen
Purified recombinant human MAP2 (N-terminus) protein fragments expressed in E.coli
Specificity
This antibody detects endogenous levels of MAP2 (N-terminus) and does not cross-react with related proteins.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
wb dilution 1:1000 icc dilution 1:150
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010],
Function
alternative products:Additional isoforms seem to exist,function:The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.,PTM:MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 3 Tau/MAP repeats.,similarity:Contains 4 Tau/MAP repeats.,
Other name
DKFZp686I2148;Dendrite specific MAP;DKFZp686I2148;MAP 2;MAP dendrite specific;MAP-2; MAP2;MAP2A;MAP2B;MAP2C;Microtubule associated protein 2;Microtubule-associated protein 2;Mtap 2;MTAP2_HUMAN.
Human protein sequence Database
P11137
Mouse protein sequence database
P20357
Rat protein sequence database
Cellular localization
Cytoplasm, cytoskeleton . Cell projection, dendrite .
Tissue expression
Brain,Brain cortex,Epithelium,Pancreas,Testis,
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