Molecular weight (DA)
48kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Ameloblastin. AA range:275-324
Specificity
Ameloblastin Polyclonal Antibody detects endogenous levels of Ameloblastin protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes the nonamelogenin enamel matrix protein ameloblastin. The encoded protein may be important in enamel matrix formation and mineralization. This gene is located in the calcium-binding phosphoprotein gene cluster on chromosome 4. Mutations in this gene may be associated with dentinogenesis imperfect and autosomal dominant amylogenesis imperfect. [provided by RefSeq, Aug 2011],
Function
disease:Defects in AMBN are found in patients with ameloblastomas.,function:Involved in the mineralization and structural organization of enamel.,similarity:Belongs to the ameloblastin family.,tissue specificity:Ameloblast-specific. Located at the Tomes processes of secretory ameloblasts and in the sheath space between rod-interrod enamel.,
Protein name
Ameloblastin
Abbreviation
Ameloblastin
Other name
AMBN; Ameloblastin
Human protein sequence Database
Q9NP70
Mouse protein sequence database
O55189
Rat protein sequence database
Cellular localization
Secreted, extracellular space, extracellular matrix.
Tissue expression
Ameloblast-specific. Located at the Tomes processes of secretory ameloblasts and in the sheath space between rod-interrod enamel.
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