Immunogen
The antiserum was produced against synthesized peptide derived from human CIB2. AA range:21-70
Specificity
CIB2 Polyclonal Antibody detects endogenous levels of CIB2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. The encoded protein is a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs), and it is involved in photoreceptor cell maintenance. Mutations in this gene cause deafness, autosomal recessive, 48 (DFNB48), and also Usher syndrome 1J (USH1J). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
Function
similarity:Contains 3 EF-hand domains.,tissue specificity:Ubiquitous.,
Protein name
Calcium and integrin-binding family member 2
Other name
CIB2; KIP2; Calcium and integrin-binding family member 2; Kinase-interacting protein 2; KIP 2
Human protein sequence Database
O75838
Mouse protein sequence database
Q9Z309
Rat protein sequence database
Q568Z7
Cellular localization
Cytoplasm . Cell projection, stereocilium . Photoreceptor inner segment . Cell projection, cilium, photoreceptor outer segment . Cell membrane, sarcolemma . Colocalized with ITGA7 at the myotendinous junctions (MTJ) and at the neuromuscular junctions (NMJ) (By similarity). Localizes in the cuticular plate along and at the tip of the stereocilia of vestibular sensory hair cells (PubMed:26173970, PubMed:26426422). .
Tissue expression
Widely expressed (PubMed:23023331).
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