Molecular weight (DA)
55kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Thyroid Hormone Receptor alpha. AA range:10-59
Specificity
TRα Polyclonal Antibody detects endogenous levels of TRα protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],
Function
domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,function:Nuclear hormone receptor. High affinity receptor for triiodothyronine.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with C1D (By similarity). Interacts with AKAP13.,
Protein name
Thyroid hormone receptor alpha
Other name
THRA; EAR7; ERBA1; NR1A1; THRA1; THRA2; Thyroid hormone receptor alpha; Nuclear receptor subfamily 1 group A member 1; V-erbA-related protein 7; EAR-7; c-erbA-1; c-erbA-alpha
Fields
>>Neuroactive ligand-receptor interaction;>>Thyroid hormone signaling pathway
Human protein sequence Database
P10827
Mouse protein sequence database
P63058
Rat protein sequence database
P63059
Cellular localization
Nucleus.; [Isoform Alpha-2]: Cytoplasm . Nucleus . When overexpressed found in the cytoplasm where it colocalizes with TACC1. .
Tissue expression
Brain,Brain cortex,Hippocampus,Kidney,Muscle,Testis,
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