Molecular weight (DA)
70kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 150-230
Specificity
PIF1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a DNA-dependent adenosine triphosphate (ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents telomere elongation by inhibiting the actions of telomerase. Alternative splicing and the use of alternative start codons results in multiple isoforms that are differentially localized to either the mitochondria or the nucleus. [provided by RefSeq, Nov 2013],
Function
function:DNA-dependent ATPase and DNA helicase inhibiting telomerase activity by unwinding DNA/RNA duplex formed by telomerase RNA and telomeric DNA in a 5' to 3' polarity. Negatively regulates telomere length and such inhibition requires its ATPase activity. Tightly cell cycle regulated and expressed in late S/G2 phase.,similarity:Belongs to the helicase family.,subunit:Interacts with telomerase.,tissue specificity:Weak ubiquitous expression.,
Protein name
ATP-dependent DNA helicase PIF1 (EC 3.6.4.12) (PIF1/RRM3 DNA helicase-like protein)
Human protein sequence Database
Q9H611
Mouse protein sequence database
Q80SX8
Rat protein sequence database
Q1HG60
Cellular localization
Nucleus .; [Isoform 4]: Mitochondrion .
Tissue expression
Weak ubiquitous expression.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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