Molecular weight (DA)
90kD
Immunogen
Purified recombinant human Hsp90 beta protein fragments expressed in E.coli
Specificity
This antibody detects endogenous levels of Hsp90 beta and does not cross-react with Hsp90 alpha and other proteins.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
wb dilution 1:2000 icc dilution 1:200
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012],
Function
function:Molecular chaperone. Has ATPase activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with TP53/p53 (By similarity). Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer.,
Other name
HSP90AB1;90 kda heat shock protein beta HSP90 beta;D6S182;FLJ26984;Heat shock 84 kDa;Heat shock 90kD protein 1, beta;Heat shock 90kDa protein 1 beta;Heat shock protein 90kDa alpha (cytosolic) class B member 1;Heat shock protein beta;Heat shock protein HSP 90 beta;Heat shock protein HSP 90-beta;HS90B_HUMAN;HSP 84;HSP 90;HSP 90 b;HSP 90b;HSP84;HSP90 BETA;hsp90ab1;HSP90B;HSPC2;HSPCB.
Fields
>>Protein processing in endoplasmic reticulum;>>PI3K-Akt signaling pathway;>>Necroptosis;>>Antigen processing and presentation;>>NOD-like receptor signaling pathway;>>IL-17 signaling pathway;>>Th17 cell differentiation;>>Progesterone-mediated oocyte maturation;>>Estrogen signaling pathway;>>Salmonella infection;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>Prostate cancer;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis
Human protein sequence Database
P08238
Mouse protein sequence database
P11499
Rat protein sequence database
Cellular localization
Cytoplasm . Melanosome . Nucleus . Secreted . Cell membrane . Dynein axonemal particle . Cell surface . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Translocates with BIRC2 from the nucleus to the cytoplasm during differentiation (PubMed:18239673). Secreted when associated with TGFB1 processed form (LAP) (PubMed:20599762). .
Tissue expression
Amygdala,Brain cortex,Colon,Colon carcinoma,Embryon
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