Molecular weight (DA)
58kD
Immunogen
The antiserum was produced against synthesized peptide derived from human STAM2 around the phosphorylation site of Tyr192. AA range:161-210
Specificity
Phospho-STAM2 (Y192) Polyclonal Antibody detects endogenous levels of STAM2 protein only when phosphorylated at Y192.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008],
Function
domain:Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.,domain:The SH3 domain mediates the interaction with USP8.,domain:The VHS and UIM domains mediate the interaction with ubiquitinated proteins.,function:Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential
Protein name
Signal transducing adapter molecule 2
Other name
STAM2; HBP; Signal transducing adapter molecule 2; STAM-2; Hrs-binding protein
Fields
>>Endocytosis;>>JAK-STAT signaling pathway
Human protein sequence Database
O75886
Mouse protein sequence database
O88811
Rat protein sequence database
Cellular localization
Cytoplasm . Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side .
Tissue expression
Ubiquitously expressed.
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