Molecular weight (DA)
75kD
Immunogen
Synthesized phospho-peptide around the phosphorylation site of human Gab 2 (phospho Tyr452)
Specificity
Phospho-Gab 2 (Y452) Polyclonal Antibody detects endogenous levels of Gab 2 protein only when phosphorylated at Y452.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
GRB2 associated binding protein 2(GAB2) Homo sapiens This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009],
Function
PTM:Dephosphorylated by PTPN11.,PTM:Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R.,similarity:Belongs to the GAB family.,similarity:Contains 1 PH domain.,subunit:Interacts with GRB2, PI-3 kinase and with other SH2-containing proteins.,
Protein name
GRB2-associated-binding protein 2
Other name
GAB2; KIAA0571; GRB2-associated-binding protein 2; GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2; pp100
Fields
>>Ras signaling pathway;>>Sphingolipid signaling pathway;>>Phospholipase D signaling pathway;>>Osteoclast differentiation;>>Fc epsilon RI signaling pathway;>>Fc gamma R-mediated phagocytosis;>>Chronic myeloid leukemia
Human protein sequence Database
Q9UQC2
Mouse protein sequence database
Q9Z1S8
Rat protein sequence database
Q9EQH1
Cellular localization
Cytoplasm . Cell membrane .
Tissue expression
Brain,Clones donated by Kazusa DNA Research Inst.,
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