Immunogen
The antiserum was produced against synthesized peptide derived from human PPP1R2 around the phosphorylation site of Ser120 and Ser121. AA range:86-135
Specificity
Phospho-IPP-2 (S120/S121) Polyclonal Antibody detects endogenous levels of IPP-2 protein only when phosphorylated at S120/S121.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015],
Function
function:Inhibitor of protein-phosphatase 1.,PTM:Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex (By similarity). Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex.,similarity:Belongs to the protein phosphatase inhibitor 2 family.,subunit:Heterodimer with PP1.,
Protein name
Protein phosphatase inhibitor 2
Other name
PPP1R2; IPP2; Protein phosphatase inhibitor 2; IPP-2
Human protein sequence Database
P41236
Mouse protein sequence database
Q9DCL8
Rat protein sequence database
P50411
Cellular localization
protein phosphatase type 1 complex,
Tissue expression
Epithelium,Heart,Platelet,Skin,Testis,
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