Molecular weight (DA)
80kD
Immunogen
Synthesized phosho peptide around human REPS1 (Ser709)
Specificity
This antibody detects endogenous levels of Human REPS1 (phospho-Ser709)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a signaling adaptor protein with two EH domains that interacts with proteins that participate in signaling, endocytosis and cytoskeletal changes. The encoded protein has been found in association with intersectin 1 and Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1 when intersectin 1 was isolated from clathrin-coated pits. The encoded protein has also been shown to interact with amphiphysin, a cytoplasmic protein at the surface of synaptic vesicles. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014],
Function
function:May coordinate the cellular actions of activated EGF receptors and Ral-GTPases.,PTM:EGF stimulates phosphorylation on Tyr-residues.,similarity:Contains 1 EF-hand domain.,similarity:Contains 1 EH domain.,subunit:Homodimer (Potential). Interacts with RAB11FIP2. Interacts with RALBP1, CRK and GRB2. Binding to RALBP1 does not affect its Ral-binding activity. Forms a complex with the SH3 domains of CRK and GRB2 which may link it to an EGF-responsive tyrosine kinase.,
Protein name
REPS1 (Ser709)
Other name
RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1)
Human protein sequence Database
Q96D71
Mouse protein sequence database
O54916
Rat protein sequence database
Cellular localization
Membrane, clathrin-coated pit . Colocalize with ITSN1 at the plasma membrane in structures that are most probably clathrin-coated pits.
Tissue expression
Widely expressed with highest levels in heart and testis.
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