Immunogen
Synthesized peptide derived from human NLRC4 AA range: 481-531
Specificity
This antibody detects endogenous levels of NLRC4 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014],
Function
function:Plays a role in the promotion of apoptosis.,similarity:Contains 1 CARD domain.,similarity:Contains 1 NACHT domain.,similarity:Contains 14 LRR (leucine-rich) repeats.,subcellular location:Cytoplasmic filaments.,subunit:Self-associates and binds to ASC, pro-caspase-1, NOD2, BCL10 and NALP1 (NAC) by CARD-CARD interaction.,tissue specificity:Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.,
Gene Name
NLRC4 CARD12 CLAN CLAN1 IPAF UNQ6189/PRO20215
Fields
>>NOD-like receptor signaling pathway;>>Shigellosis;>>Salmonella infection;>>Legionellosis;>>Yersinia infection
Human protein sequence Database
Q9NPP4
Mouse protein sequence database
Q3UP24
Rat protein sequence database
F1M649
Cellular localization
Cytoplasm . Cytoplasm, cytosol . Inflammasome .
Tissue expression
Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.
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