Molecular weight (DA)
190kD
Immunogen
Synthesized phosho peptide around human Rictor (Thr1135)
Specificity
This antibody detects endogenous levels of Human Mouse Rictor (phospho-Thr1135)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008],
Function
function:Plays an essential role in embryonic growth and development (By similarity). Part of the TORC2 complex which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.,similarity:Belongs to the pianissimo family.,subunit:Forms part of the target of rapamycin 2 complex (TORC2) comprised of FRAP1, LST8, PROTOR1, RICTOR and MAPKAP1. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to FRAP1 and PROTOR1 within the TORC2 complex. May interact with PROTOR2.,
Gene Name
RICTOR KIAA1999
Protein name
Rictor (Thr1135)
Other name
Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3)
Fields
>>mTOR signaling pathway
Human protein sequence Database
Q6R327
Mouse protein sequence database
Q6QI06
Rat protein sequence database
Cellular localization
cytosol,TORC2 complex,
Tissue expression
Amygdala,Brain,Epithelium,Lymph,
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