Molecular weight (DA)
30kD
Immunogen
Synthesized peptide derived from human 14-3-3σ (Phospho Ser186)
Specificity
This antibody detects endogenous levels of Human,Mouse 14-3-3σ (Phospho Ser186)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.,function:p53-regulated inhibitor of G2/M progression.,similarity:Belongs to the 14-3-3 family.,subcellular location:May be secreted by a non-classical secretory pathway.,subunit:Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN.,tissue specificity:Present mainly in tissues enriched in stratified squamous keratinising epithelium.,
Function
function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.,function:p53-regulated inhibitor of G2/M progression.,similarity:Belongs to the 14-3-3 family.,subcellular location:May be secreted by a non-classical secretory pathway.,subunit:Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN.,tissue specificity:Present mainly in tissues enriched in stratified squamous keratinising epithelium.,
Protein name
14-3-3σ (Phospho Ser186)
Other name
14-3-3 protein sigma (Epithelial cell marker protein 1;Stratifin)
Fields
>>Cell cycle;>>p53 signaling pathway;>>Aldosterone-regulated sodium reabsorption
Human protein sequence Database
P31947
Mouse protein sequence database
O70456
Rat protein sequence database
Cellular localization
Cytoplasm. Nucleus . Secreted. May be secreted by a non-classical secretory pathway.
Tissue expression
Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车