Molecular weight (DA)
80kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ARPP21. AA range:211-260
Specificity
ARPP-21 Polyclonal Antibody detects endogenous levels of ARPP-21 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012],
Function
function:Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.,PTM:Isoform 1 is methylated by CARM1 in immature thymocytes.,PTM:Phosphorylation at Ser-56 favors interaction with CALM1.,similarity:Contains 1 R3H domain.,subunit:Interacts with CALM1.,tissue specificity:Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level).,
Protein name
cAMP-regulated phosphoprotein 21
Other name
ARPP21; TARPP; cAMP-regulated phosphoprotein 21; ARPP-21; Thymocyte cAMP-regulated phosphoprotein
Human protein sequence Database
Q9UBL0
Mouse protein sequence database
Q9DCB4
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level).
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