Immunogen
The antiserum was produced against synthesized peptide derived from human BAI2. AA range:91-140
Specificity
BAI-2 Polyclonal Antibody detects endogenous levels of BAI-2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014],
Function
function:Might be involved in angiogenesis inhibition.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 4 TSP type-1 domains.,subunit:Interacts with GABPB2.,tissue specificity:Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines.,
Protein name
Brain-specific angiogenesis inhibitor 2
Other name
BAI2; Brain-specific angiogenesis inhibitor 2
Human protein sequence Database
O60241
Mouse protein sequence database
Q8CGM1
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines.
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