Molecular weight (DA)
58kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
PDE1B Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011],
Function
catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,enzyme regulation:Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+).,function:Has a preference for cGMP as a substrate.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,subunit:Homodimer.,
Gene Name
PDE1B PDE1B1 PDES1B
Protein name
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE)
Fields
>>Purine metabolism;>>Metabolic pathways;>>Calcium signaling pathway;>>Olfactory transduction;>>Taste transduction;>>Renin secretion;>>Morphine addiction
Human protein sequence Database
Q01064
Mouse protein sequence database
Q01065
Rat protein sequence database
Q01066
Cellular localization
Cytoplasm, cytosol .
Tissue expression
Brain,Human uterus,Testis,
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车