Immunogen
The antiserum was produced against synthesized peptide derived from human Defensin alpha3. AA range:3-52
Specificity
Defensin α3 Polyclonal Antibody detects endogenous levels of Defensin α3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
defensin alpha 3(DEFA3) Homo sapiens Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation. [provided by RefSeq, Oct 2014],
Function
function:Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.,similarity:Belongs to the alpha-defensin family.,subunit:Dimer.,
Protein name
Neutrophil defensin 3
Other name
DEFA3; DEF3; Neutrophil defensin 3; Defensin; alpha 3; HNP-3; HP-3; HP3
Fields
>>NOD-like receptor signaling pathway;>>Staphylococcus aureus infection;>>Transcriptional misregulation in cancer
Human protein sequence Database
P59666
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Pancreas,PCR rescued clones,Spleen,
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