Molecular weight (DA)
85kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NADAP. AA range:421-470
Specificity
Kanadaptin Polyclonal Antibody detects endogenous levels of Kanadaptin protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
caution:PubMed:15764369 initially suggested a role in targeting SLC4A1 (kidney anion exchanger 1) to the plasma membrane; it does not seem to do so as it does not interact with SLC4A1 and has no effect on SLC4A1 trafficking.,online information:Band 3 entry,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 FHA domain.,subcellular location:Mainly nuclear. Small amounts are found in the cytoplasm.,tissue specificity:Ubiquitously expressed.,
Function
caution:PubMed:15764369 initially suggested a role in targeting SLC4A1 (kidney anion exchanger 1) to the plasma membrane; it does not seem to do so as it does not interact with SLC4A1 and has no effect on SLC4A1 trafficking.,online information:Band 3 entry,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 FHA domain.,subcellular location:Mainly nuclear. Small amounts are found in the cytoplasm.,tissue specificity:Ubiquitously expressed.,
Other name
SLC4A1AP; HLC3; Kanadaptin; Human lung cancer oncogene 3 protein; HLC-3; Kidney anion exchanger adapter protein; Solute carrier family 4 anion exchanger member 1 adapter protein
Human protein sequence Database
Q9BWU0
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm . Mainly nuclear. Small amounts are found in the cytoplasm.
Tissue expression
Ubiquitously expressed.
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