Immunogen
Synthesized peptide derived from the C-terminal region of human EDEM2.
Specificity
EDEM2 Polyclonal Antibody detects endogenous levels of EDEM2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed 15537790]).[supplied by OMIM, Mar 2008],
Function
similarity:Belongs to the glycosyl hydrolase 47 family.,
Protein name
ER degradation-enhancing alpha-mannosidase-like 2
Other name
EDEM2; C20orf31; C20orf49; ER degradation-enhancing alpha-mannosidase-like 2
Fields
>>Protein processing in endoplasmic reticulum
Human protein sequence Database
Q9BV94
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Endoplasmic reticulum lumen .
Tissue expression
Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle.
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