Molecular weight (DA)
29kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
HHEX Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008],
Function
developmental stage:Expressed during hematopoiesis.,function:Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL.,similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Liver and promyelocytic leukemia cell line HL60.,
Gene Name
HHEX HEX PRH PRHX
Protein name
Hematopoietically-expressed homeobox protein HHEX (Homeobox protein HEX) (Homeobox protein PRH)
Fields
>>Maturity onset diabetes of the young;>>Transcriptional misregulation in cancer
Human protein sequence Database
Q03014
Mouse protein sequence database
P43120
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Liver and promyelocytic leukemia cell line HL-60.
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