Molecular weight (DA)
50kD
Immunogen
Synthesized peptide derived from GPT2 . at AA range: 190-270
Specificity
GPT2 Polyclonal Antibody detects endogenous levels of GPT2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],
Function
catalytic activity:L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.,cofactor:Pyridoxal phosphate.,pathway:Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.,similarity:Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.,subunit:Homodimer.,tissue specificity:Expressed at high levels in muscle, adipose tissue, kidney and brain and at lower levels in the liver and breast.,
Protein name
Alanine aminotransferase 2
Other name
GPT2; AAT2; ALT2; Alanine aminotransferase 2; ALT2; Glutamate pyruvate transaminase 2; GPT 2; Glutamic--alanine transaminase 2; Glutamic--pyruvic transaminase 2
Fields
>>Arginine biosynthesis;>>Alanine, aspartate and glutamate metabolism;>>Metabolic pathways;>>Carbon metabolism;>>2-Oxocarboxylic acid metabolism;>>Biosynthesis of amino acids
Human protein sequence Database
Q8TD30
Mouse protein sequence database
Q8BGT5
Rat protein sequence database
Cellular localization
mitochondrion,mitochondrial matrix,
Tissue expression
Expressed at high levels in muscle, adipose tissue, kidney and brain and at lower levels in the liver and breast.
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