Molecular weight (DA)
15kD
Immunogen
The antiserum was produced against synthesized peptide derived from human IFM3. AA range:1-50
Specificity
IFITM3 Polyclonal Antibody detects endogenous levels of IFITM3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012],
Function
induction:By alpha and gamma interferons.,similarity:Belongs to the CD225 family.,
Protein name
Interferon-induced transmembrane protein 3
Other name
IFITM3; Interferon-induced transmembrane protein 3; Dispanin subfamily A member 2b; DSPA2b; Interferon-inducible protein 1-8U
Human protein sequence Database
Q01628
Mouse protein sequence database
Q9CQW9
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type II membrane protein . Late endosome membrane ; Single-pass type II membrane protein . Early endosome membrane ; Single-pass type II membrane protein. Lysosome membrane ; Single-pass type II membrane protein . Cytoplasm, perinuclear region . Co-localizes with BRI3 isoform 1 at the perinuclear region. .
Tissue expression
Brain,Cervix,Vascular endothelial cell,
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