Molecular weight (DA)
59kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 210-290
Specificity
CDY1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined. [provided by
Function
catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone.,function:Has histone acetyltransferase activity, with a preference for histone H4.,similarity:Contains 1 chromo domain.,tissue specificity:Testis specific.,
Gene Name
CDY1 CDY1A; CDY1B
Protein name
Testis-specific chromodomain protein Y 1 (EC 2.3.1.48)
Human protein sequence Database
Q9Y6F8
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Testis-specific. Detected in spermatids (at protein level).
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