Molecular weight (DA)
57kD
Immunogen
The antiserum was produced against synthesized peptide derived from human BAIAP2L1. AA range:111-160
Specificity
IRTKS Polyclonal Antibody detects endogenous levels of IRTKS protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal fo
Function
domain:The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation.,function:May function as adapter protein (Potential). Involved in the formation of clusters of actin bundles.,PTM:Phosphorylated on tyrosine in response to insulin.,similarity:Contains 1 IMD (IRSp53/MIM homology) domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with RAC1. Binds to F-actin.,
Protein name
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
Other name
BAIAP2L1; IRTKS; Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; BAI1-associated protein 2-like protein 1; Insulin receptor tyrosine kinase substrate
Fields
>>Pathogenic Escherichia coli infection
Human protein sequence Database
Q9UHR4
Mouse protein sequence database
Q9DBJ3
Rat protein sequence database
Q3KR97
Cellular localization
Cytoplasm, cytoskeleton . Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
Tissue expression
Adrenal gland,Epithelium,Lung,Placenta,
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车