Molecular weight (DA)
136kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
JAG2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
disease:May be associated with Usher syndrome type IA (USHA1A) which describes a congenital sensory deafness associated with retinitis pigmentosa and feeble-mindedness.,function:Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development.,similarity:Contains 1 DSL domain.,similarity:Contains 1 VWFC domain.,similarity:Contains 16 EGF-like domains.,tissue specificity:Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney.,
Protein name
Protein jagged-2 (Jagged2) (hJ2)
Fields
>>Endocrine resistance;>>Notch signaling pathway;>>Th1 and Th2 cell differentiation;>>Pathways in cancer;>>Breast cancer
Human protein sequence Database
Q9Y219
Mouse protein sequence database
Q9QYE5
Rat protein sequence database
P97607
Cellular localization
Membrane; Single-pass type I membrane protein.
Tissue expression
Expressed in heart, placenta and skeletal muscle and to a lesser extent in pancreas. Very low expression in brain, lung, liver and kidney.
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