Molecular weight (DA)
32kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MRPL46. AA range:111-160
Specificity
MRP-L46 Polyclonal Antibody detects endogenous levels of MRP-L46 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008],
Function
similarity:Belongs to the ribosomal protein L46 family.,
Protein name
39S ribosomal protein L46 mitochondrial
Other name
MRPL46; C15orf4; LIECG2; 39S ribosomal protein L46; mitochondrial; L46mt; MRP-L46; P2ECSL
Human protein sequence Database
Q9H2W6
Mouse protein sequence database
Q9EQI8
Rat protein sequence database
Q5RK00
Cellular localization
Mitochondrion .
Tissue expression
Skeletal muscle,Spleen,
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