Molecular weight (DA)
60kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PPP1R16A. AA range:362-411
Specificity
MYPT3 Polyclonal Antibody detects endogenous levels of MYPT3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000; IF/ICC 1:50-200;ELISA 1:2000-20000;IHC-p 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while other MYPTs result in PP1c activation after becoming phosphorylated, the encoded protein is phosphorylated by protein kinase A and then inhibits the catalytic activity of PP1c. [provided by RefSeq, Jul 2016],
Function
function:Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.,sequence caution:Cloning artifact.,similarity:Contains 5 ANK repeats.,subunit:Binds PP1.,
Protein name
Protein phosphatase 1 regulatory subunit 16A
Other name
PPP1R16A; MYPT3; Protein phosphatase 1 regulatory subunit 16A; Myosin phosphatase-targeting subunit 3
Human protein sequence Database
Q96I34
Mouse protein sequence database
Q923M0
Rat protein sequence database
Cellular localization
Cell membrane ; Lipid-anchor .
Tissue expression
Lung,Placenta,Spleen,Uterus,
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