Immunogen
The antiserum was produced against synthesized peptide derived from human MEF2A around the phosphorylation site of Thr319. AA range:296-345
Specificity
Phospho-MEF-2 (T319) Polyclonal Antibody detects endogenous levels of MEF-2 protein only when phosphorylated at T319.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010],
Function
disease:Defects in MEF2A might be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1) [MIM:608320].,function:Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation.,PTM:Acetylation on Lys-403 activates transcriptional activity. Acetylated by p300 on several sites in di
Protein name
Myocyte-specific enhancer factor 2A
Other name
MEF2A; MEF2; Myocyte-specific enhancer factor 2A; Serum response factor-like protein 1
Fields
>>cGMP-PKG signaling pathway;>>Apelin signaling pathway;>>Parathyroid hormone synthesis, secretion and action;>>Fluid shear stress and atherosclerosis
Human protein sequence Database
Q02078
Mouse protein sequence database
Q60929
Rat protein sequence database
Q2MJT0
Cellular localization
Nucleus .
Tissue expression
Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. Isoform RSRFC4 and isoform RSRFC9 are expressed in all tissues examined.
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