Immunogen
Synthesized peptide derived from the C-terminal region of human Podocan.
Specificity
Podocan Polyclonal Antibody detects endogenous levels of Podocan protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the small leucine-rich repeat protein family and contains an amino terminal CX3CXCX7C cysteine-rich cluster followed by a leucine-rich repeat domain. Studies suggest that this protein could function to inhibit smooth muscle cell proliferation and migration following arterial injury. [provided by RefSeq, Jul 2016],
Function
PTM:N-glycosylated.,similarity:Belongs to the small leucine-rich proteoglycan (SLRP) family. Class V subfamily.,similarity:Contains 20 LRR (leucine-rich) repeats.,subunit:Binds to type I collagen.,tissue specificity:Kidney, heart, liver, pancreas and vascular smooth muscle cells.,
Other name
PODN; SLRR5A; Podocan
Human protein sequence Database
Q7Z5L7
Mouse protein sequence database
Q7TQ62
Rat protein sequence database
Cellular localization
[Isoform 1]: Secreted, extracellular space, extracellular matrix.; [Isoform 2]: Cytoplasm .; [Isoform 3]: Cytoplasm .; [Isoform 4]: Cytoplasm .
Tissue expression
Kidney, heart, liver, pancreas and vascular smooth muscle cells. Also detected in aortic intima (at protein level).
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