Molecular weight (DA)
42kD
Immunogen
Synthesized peptide derived from Septin 5 . at AA range: 180-260
Specificity
Septin 5 Polyclonal Antibody detects endogenous levels of Septin 5 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
septin 5(SEPT5) Homo sapiens This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq, Dec 2010],
Function
function:Involved in cytokinesis .,similarity:Belongs to the septin family.,subunit:May assemble into a multicomponent structure.,
Other name
SEPT5; PNUTL1; Septin-5; Cell division control-related protein 1; CDCrel-1; Peanut-like protein 1
Fields
>>Parkinson disease;>>Pathways of neurodegeneration - multiple diseases
Human protein sequence Database
Q99719
Mouse protein sequence database
Q9Z2Q6
Rat protein sequence database
Q9JJM9
Cellular localization
Cytoplasm . Cytoplasm, cytoskeleton . In platelets, found in areas surrounding alpha-granules.
Tissue expression
Expressed at high levels in the CNS, as well as in heart and platelets (at protein level).
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