Molecular weight (DA)
22kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Syndecan4. AA range:145-194
Specificity
Syndecan-4 Polyclonal Antibody detects endogenous levels of Syndecan-4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008],
Function
function:Cell surface proteoglycan that bears heparan sulfate.,function:Cell surface proteoglycan.,similarity:Belongs to the syndecan proteoglycan family.,subunit:Homodimer. Interacts with CDCP1, with GIPC PDZ domain and with NUDT16L1/SDOS (By similarity). Interacts with SDCBP.,tissue specificity:Expressed in epithelial and fibroblastic cells.,
Other name
SDC4; Syndecan-4; SYND4; Amphiglycan; Ryudocan core protein
Fields
>>ECM-receptor interaction;>>Cell adhesion molecules;>>Proteoglycans in cancer;>>Fluid shear stress and atherosclerosis
Human protein sequence Database
P31431
Mouse protein sequence database
O35988
Rat protein sequence database
P34901
Cellular localization
[Isoform 1]: Membrane ; Single-pass type I membrane protein . Secreted . Shedding of the ectodomain produces a soluble form. .; [Isoform 2]: Secreted.
Tissue expression
Expressed in epithelial and fibroblastic cells.
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