Immunogen
The antiserum was produced against synthesized peptide derived from human STEA2. AA range:431-480
Specificity
STEAP2 Polyclonal Antibody detects endogenous levels of STEAP2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
STEAP2 metalloreductase(STEAP2) Homo sapiens This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
Function
cofactor:FAD.,function:Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.,similarity:Belongs to the STEAP family.,similarity:Contains 1 ferric oxidoreductase domain.,tissue specificity:Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.,
Protein name
Metalloreductase STEAP2
Other name
STEAP2; PCANAP1; STAMP1; Metalloreductase STEAP2; Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; PUMPCn; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1
Fields
>>Mineral absorption
Human protein sequence Database
Q8NFT2
Mouse protein sequence database
Q8BWB6
Rat protein sequence database
Cellular localization
Endosome membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein .
Tissue expression
Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.
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