Molecular weight (DA)
62kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TBC1D3. AA range:481-530
Specificity
TBC1D3A/B/C Polyclonal Antibody detects endogenous levels of TBC1D3A/B/C protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene represents one of a cluster of related genes found on chromosome 17. The proteins encoded by this gene family contain a TBC (Tre-2, Bub2p, and Cdc16p) domain and may be involved in GTPase signaling and vesicle trafficking. [provided by RefSeq, Apr 2014],
Function
disease:May be involved in forms of prostate cancers.,function:Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11.,similarity:Contains 1 Rab-GAP TBC domain.,tissue specificity:Expressed in liver, skeletal muscle, kidney, pancreas, spleen, testis, ovary, small intestine and peripheral blood leukocytes. Overexpressed in prostate cancers.,tissue specificity:Expressed in pancreas, thymus and testis.,
Protein name
TBC1 domain family member 3
Other name
TBC1D3; PRC17; TBC1D3A; TBC1 domain family member 3; Prostate cancer gene 17 protein; Protein TRE17-alpha; Rab GTPase-activating protein PRC17; TBC1D3B; TBC1D3I; TBC1 domain family member 3B; TBC1D3C; TBC1D3D; TBC1 domain family member 3C
Human gene ID
414059/727735/84218/643947/414060/653380/654341/729873
Human protein sequence Database
Q8IZP1/A6NDS4/Q6IPX1
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell membrane ; Lipid-anchor . Associated with lipid rafts.
Tissue expression
Expressed in liver, skeletal muscle, kidney, pancreas, spleen, testis, ovary, small intestine and peripheral blood leukocytes. Overexpressed in prostate cancers.
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