Molecular weight (DA)
57kD
Immunogen
The antiserum was produced against synthesized peptide derived from human B3GALTL. AA range:449-498
Specificity
β-1,3-Gal-TL Polyclonal Antibody detects endogenous levels of β-1,3-Gal-TL protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a beta-1,3-glucosyltransferase that transfers glucose to O-linked fucosylglycans on thrombospondin type-1 repeats (TSRs) of several proteins. The encoded protein is a type II membrane protein. Defects in this gene are a cause of Peters-plus syndrome (PPS).[provided by RefSeq, Mar 2009],
Function
disease:Defects in B3GALTL are the cause of Peters-plus syndrome (PPS) [MIM:261540]. PPS is an autosomal recessive disorder characterized by anterior eye-chamber abnormalities, disproportionate short stature, developmental delay, characteristic craniofacial features, cleft lip and/or palate.,function:O-fucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan.,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 31 family.,tissue specificity:Widely expressed, with highest levels in testis and uterus.,
Protein name
Beta-1,3-glucosyltransferase
Abbreviation
β-1,3-Gal-TL
Other name
B3GALTL; B3GTL; Beta-1; 3-glucosyltransferase; Beta3Glc-T; Beta-3-glycosyltransferase-like
Fields
>>Other types of O-glycan biosynthesis
Human protein sequence Database
Q6Y288
Mouse protein sequence database
Q8BHT6
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane ; Single-pass type II membrane protein .
Tissue expression
Widely expressed, with highest levels in testis and uterus.
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