Molecular weight (DA)
54kD
Immunogen
Synthesized peptide derived from the C-terminal region of human DPP7.
Specificity
DPP7 Polyclonal Antibody detects endogenous levels of DPP7 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Release of an N-terminal dipeptide, Xaa-Yaa-|-, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides.,function:Plays an important role in the degradation of some oligopeptides.,PTM:N-glycosylated.,similarity:Belongs to the peptidase S28 family.,subunit:Homodimer.,
Protein name
Dipeptidyl peptidase 2
Other name
DPP7; DPP2; QPP; Dipeptidyl peptidase 2; Dipeptidyl aminopeptidase II; Dipeptidyl peptidase 7; Dipeptidyl peptidase II; DPP II; Quiescent cell proline dipeptidase
Human protein sequence Database
Q9UHL4
Mouse protein sequence database
Q9ET22
Rat protein sequence database
Cellular localization
Lysosome . Cytoplasmic vesicle . Secreted .
Tissue expression
Detected in seminal plasma (at protein level).
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