Molecular weight (DA)
70kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human GPC3. AA range:461-510
Specificity
Glypican-3 Polyclonal Antibody detects endogenous levels of Glypican-3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009],
Function
disease:Defects in GPC3 are the cause of Simpson-Golabi-Behmel syndrome (SGBS) [MIM:312870]; also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies.,function:Cell surface proteoglycan that bears heparan sulfate.,function:Cell surface proteoglycan that bears heparan sulfate. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.,similarity:Belongs to the glypican family.,tissue specificity:Highly expressed in lung, liver and kidney.,
Other name
GPC3; OCI5; Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7
Fields
>>Proteoglycans in cancer
Human protein sequence Database
P51654
Mouse protein sequence database
Q8CFZ4
Rat protein sequence database
P13265
Cellular localization
Cell membrane ; Lipid-anchor, GPI-anchor ; Extracellular side .
Tissue expression
Highly expressed in lung, liver and kidney.
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