Molecular weight (DA)
65kD
Immunogen
The antiserum was produced against synthesized peptide derived from human FST. AA range:121-170
Specificity
Follistatin Polyclonal Antibody detects endogenous levels of Follistatin protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008],
Function
function:Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).,similarity:Contains 1 TB (TGF-beta binding) domain.,similarity:Contains 3 follistatin-like domains.,similarity:Contains 3 Kazal-like domains.,subunit:Monomer .,tissue specificity:Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid.,
Other name
FST; Follistatin; FS; Activin-binding protein
Fields
>>TGF-beta signaling pathway
Human protein sequence Database
P19883
Mouse protein sequence database
P47931
Rat protein sequence database
P21674
Cellular localization
Secreted.
Tissue expression
Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid. In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen throughout the palatal shelf and tongue mesenchyme (PubMed:31215115).
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