Molecular weight (DA)
45kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human SERPINB3/4. AA range:111-160
Specificity
SCCA1/2 Polyclonal Antibody detects endogenous levels of SCCA1/2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
developmental stage:Its expression is closely related to cellular differentiation in both normal and malignant squamous cells.,function:May act as a protease inhibitor to modulate the host immune response against tumor cells.,similarity:Belongs to the serpin family.,similarity:Belongs to the serpin family. Ov-serpin subfamily.,subcellular location:Seems to also be secreted in plasma by cancerous cells but at a low level.,tissue specificity:Squamous cells. Expressed in some hepatocellular carcinoma (at protein level).,
Function
developmental stage:Its expression is closely related to cellular differentiation in both normal and malignant squamous cells.,function:May act as a protease inhibitor to modulate the host immune response against tumor cells.,similarity:Belongs to the serpin family.,similarity:Belongs to the serpin family. Ov-serpin subfamily.,subcellular location:Seems to also be secreted in plasma by cancerous cells but at a low level.,tissue specificity:Squamous cells. Expressed in some hepatocellular carcinoma (at protein level).,
Gene Name
SERPINB3/SERPINB4
Protein name
Serpin B3/Serpin B4
Other name
SERPINB3; SCCA; SCCA1; Serpin B3; Protein T4-A; Squamous cell carcinoma antigen 1; SCCA-1
Human protein sequence Database
P29508
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm . Seems to also be secreted in plasma by cancerous cells but at a low level.
Tissue expression
Squamous cells. Expressed in some hepatocellular carcinoma (at protein level).
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