Molecular weight (DA)
34kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human WDR83. AA range:141-190
Specificity
MAPK Organizer 1 Polyclonal Antibody detects endogenous levels of MAPK Organizer 1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],
Function
function:Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing.,similarity:Belongs to the WD repeat MORG1 family.,similarity:Contains 7 WD repeats.,subcellular location:Predominantly cytoplasmic (By similarity). Partially nuclear.,subunit:Interacts with EGLN3/PHD3. Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, MAP2K1IP1/M
Protein name
WD repeat domain-containing protein 83
Abbreviation
MAPK Organizer 1
Other name
WDR83; MORG1; WD repeat domain-containing protein 83; Mitogen-activated protein kinase organizer 1; MAPK organizer 1
Human protein sequence Database
Q9BRX9
Mouse protein sequence database
Q9DAJ4
Rat protein sequence database
Q5BLX8
Cellular localization
Cytoplasm . Nucleus . Predominantly cytoplasmic. Partially nuclear. .
Tissue expression
Kidney proximal tubule,Muscle,
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