Molecular weight (DA)
25kD
Immunogen
Synthesized peptide derived from human CFAD (Cleaved-Ile26)
Specificity
This antibody detects endogenous levels of Human CFAD (Cleaved-Ile26, protein was cleaved amino acid sequence between 25-26 )
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
catalytic activity:Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.,disease:Defects in CFD are the cause of complement factor D deficiency [MIM:134350]. This deficiency predisposes to invasive meningococcal disease.,function:Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.,online information:CFD mutation db,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,
Function
immune effector process, activation of immune response, acute inflammatory response, activation of plasma proteins involved in acute inflammatory response, positive regulation of immune system process, proteolysis, defense response, inflammatory response, immune response, complement activation, complement activation, alternative pathway, humoral immune response, cell surface receptor linked signal transduction, Notch signaling pathway,response to wounding, protein processing, innate immune response, positive regulation of response to stimulus,positive regulation of immune response, protein maturation, protein maturation by peptide bond cleavage,
Protein name
CFAD (Cleaved-Ile26)
Other name
Complement factor D (EC 3.4.21.46;Adipsin;C3 convertase activator;Properdin factor D)
Fields
>>Complement and coagulation cascades;>>Staphylococcus aureus infection;>>Coronavirus disease - COVID-19
Human protein sequence Database
P00746
Mouse protein sequence database
P03953
Rat protein sequence database
P32038
Cellular localization
Secreted.
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