Molecular weight (DA)
80kD
Immunogen
Synthesized peptide derived from human ACSS2 (Acetyl Lys418)
Specificity
This antibody detects endogenous levels of Human,Mouse ACSS2 (Acetyl Lys418)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009],
Function
catalytic activity:ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.,function:Activates acetate so that it can be used for lipid synthesis or for energy generation.,similarity:Belongs to the ATP-dependent AMP-binding enzyme family.,subunit:Monomer.,
Protein name
ACSS2 (Acetyl Lys418)
Other name
Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1;Acetate--CoA ligase;Acetyl-CoA synthetase;ACS;AceCS;Acyl-CoA synthetase short-chain family member 2;Acyl-activating enzyme)
Fields
>>Glycolysis / Gluconeogenesis;>>Pyruvate metabolism;>>Glyoxylate and dicarboxylate metabolism;>>Propanoate metabolism;>>Metabolic pathways;>>Carbon metabolism
Human protein sequence Database
Q9NR19
Mouse protein sequence database
Q9QXG4
Rat protein sequence database
Cellular localization
Cytoplasm, cytosol .
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