Molecular weight (DA)
12kD
Immunogen
Synthesized peptide derived from human HMG-I/HMG-Y (Acetyl Lys65)
Specificity
This antibody detects endogenous levels of Human, Mouse, Rat HMG-I/HMG-Y (Acetyl Lys65)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016],
Function
disease:A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51L1.,function:HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.,mass spectrometry:With 1 acetyl and 2 phosphate groups PubMed:15302935,mass spectrometry:With 1 acetyl and 3 phosphate groups PubMed:15302935,mass spectrometry:With 1 acetyl, 1 methyl and 2 phosphate groups PubMed:15302935,mass spectrometry:With 1 acetyl, 1 methyl and 3 phosphate groups PubMed:15302935,mass spectrometry:With 1 acetyl, 2 methyl and 2 phosphate groups PubMed:15302935,mass spectrometry:With 1 acetyl,
Protein name
HMG-I/HMG-Y (Acetyl Lys65)
Other name
High mobility group protein HMG-I/HMG-Y (HMG-I(Y);High mobility group AT-hook protein 1;High mobility group protein A1;High mobility group protein R)
Human protein sequence Database
P17096
Mouse protein sequence database
P17095
Rat protein sequence database
Q8K585
Cellular localization
Nucleus. Chromosome.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车