Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from human ZKSC1 AA range: 313-363
Specificity
This antibody detects endogenous levels of ZKSC1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.112% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The ZKSCAN1 gene encodes a transcriptional regulator of the KRAB (Kruppel-associated box) subfamily of zinc finger proteins, which contain repeated Cys2-His2 (C2H2) zinc finger domains that are connected by conserved sequences, called H/C links (summarized by Tommerup and Vissing, 1995 [PubMed 7557990]). Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. See ZNF91 (MIM 603971) for general information on zinc finger proteins.[supplied by OMIM, Jul 2010],
Function
function:May be involved in transcriptional regulation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 1 KRAB domain.,similarity:Contains 1 SCAN box domain.,similarity:Contains 6 C2H2-type zinc fingers.,
Gene Name
ZKSCAN1 KOX18 ZNF139 ZNF36
Other name
Zinc finger protein with KRAB and SCAN domains 1 (Zinc finger protein 139) (Zinc finger protein 36) (Zinc finger protein KOX18)
Human protein sequence Database
P17029
Mouse protein sequence database
Q8BGS3
Rat protein sequence database
Q4KLI1
Cellular localization
Nucleus .
Tissue expression
Brain,Epithelium,Eye,Fetal kidney,Insulinoma,Lung,Lymphoid,Pancreas,Spleen,
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