Molecular weight (DA)
36kD
Immunogen
Purified recombinant human full length PP2A beta protein expressed in E.coli
Specificity
This antibody detects endogenous levels of PP2A alpha and PP2A beta.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010],
Function
catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 iron ion per subunit.,cofactor:Binds 1 manganese ion per subunit.,function:PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.,PTM:Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.,PTM:Reversibly methyl esterified on Leu-309. Carboxyl methylation may play a role in holoenzyme assembly. It varies during the cell cycle. Demethylated by PME1 (in vitro).,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-1 subfamily.,subcellular location:In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mito
Abbreviation
PP2A α and β
Other name
PP2A beta;PP2A-beta;PP2AB_HUMAN;PP2Abeta;PP2CB;Ppp2cb;Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform;Protein phosphatase 2 catalytic subunit beta isozyme;Protein phosphatase 2, catalytic subunit, beta isoform;Protein phosphatase 2A catalytic subunit beta isoform;Protein phosphatase type 2A catalytic subunit;Serine/threonine protein phosphatase 2A catalytic subunit beta;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform.
Fields
>>mRNA surveillance pathway;>>Sphingolipid signaling pathway;>>Oocyte meiosis;>>Autophagy - other;>>Autophagy - animal;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Adrenergic signaling in cardiomyocytes;>>TGF-beta signaling pathway;>>Hippo signaling pathway;>>Tight junction;>>Dopaminergic synapse;>>Long-term depression;>>Chagas disease;>>Hepatitis C;>>Human papillomavirus infection
Human protein sequence Database
P62714
Mouse protein sequence database
P62715
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus . Chromosome, centromere . Cytoplasm, cytoskeleton, spindle pole . In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.
Tissue expression
Fibroblast,Heart,Kidney,Liver,
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